The most common types of primary headaches are cluster headaches which are known as trigeminal autonomic cephalgia. These cluster headaches can come every other day, one to eight times a day like other trigeminal autonomic cephalgia's. Approximately, they commonly occur at same time of the day, most often at night. Many patients are periodic, with daily attacks for weeks to months, followed by remission for months to years. As cluster headaches are rare, they can be significantly exhausting, leading to a highly reduction in quality of life. The prevalence and incidence of cluster headaches are rising, which is augmenting the demand for effective treatments which is a key driving factor. Moreover, currently, there are no FDA-approved medications especially for the cluster headaches treatment. This implies that there is a major unmet requirement for effective treatments for this condition, which is augmenting the research and development efforts in this area. On the other hand, the factors limiting the cluster headache market growth are adverse effects of cluster headache drugs. The Cluster Headache Market is anticipated to grow at a rate of 3.9% CAGR by 2027.

Cluster Headache Market by Drug class

• Ergot derivatives

• Calcium channel blockers

• Triptans

• Others

Cluster Headache Market by Distribution channel

• Hospital pharmacies

• Drug stores and retail pharmacies

• Others

Cluster Headache Market by Type

• Episodic

• Chronic

Cluster Headache Market by Geography

• North America

• Europe

• Asia Pacific

• Rest of the World

The cluster headache market by drug class is divided into Ergot derivatives, Calcium channel blockers, Triptans and Others. The triptans segment holds the maximum share in the market growth. The maximum share of the segment is owing to the first line treatment for cluster headache. Triptans are a class, or group, of medicines which can stop migraine episodes. These drugs work to decrease symptoms by building enlarged blood arteries in the brain brought on by migraine attacks. Also, they are present in various dose formulations.

On the basis of distribution channel, the cluster headache market is categorized into Hospital pharmacies, Drug stores and retail pharmacies and Others. The drug stores and retail pharmacies segment held the maximum share in the market growth. This is due to the increase in consumer preference for retail pharmacies, which provide advice on drugs and their use throughout treatment periods and they also provide affordable prices.

As per the type the cluster headache market is bifurcated into Episodic and Chronic. The episodic segment accounted for the major share in the cluster headache market. The major share is owing to the surge in number of people suffering from episodic attack and increase in regulatory approval of drugs indicated for episodic cluster headache.

The regional market is divided into North America, Europe, Asia Pacific and rest of the world. North America region has occupied the major share in the cluster headache market growth due to the factors such as surge in prevalence of cluster headache cases, incidence of advanced healthcare infrastructure and rise in number of key players providing new therapeutics.

Several organizations coupled with governments across the world are counseling people about the headache disorders. E-commerce (electronic commerce) has become a significant tool for small and large businesses globally, owing to increase in preference of consumers for online shopping over conventional purchasing methods. Several animations through health apps to educate people about headache disorders and usage of medications have lead towards the growth of global cluster headache market.

Key players operating in the cluster headache market include Dr. Reddy’s Laboratories Ltd., Eli Lilly and Company, Sun Pharmaceutical Industries Ltd., Teva Pharmaceutical Industries Ltd., FRESENIUS SE & Co. KGaA, GlaxoSmithKline plc, Pfizer Inc., Arrotex Australia Group, Grunenthal, and Novartis AG.

As a result, the there is a major unmet requirement for effective treatments for cluster headaches. Henceforth, there is a rising focus on the development of new treatments, such as new pharmacological agents and neuromodulation devices which is projected to augment innovation in the market.

• Complete information on factors is provided which will propel cluster headache market growth in the forecast period.

• This report gives the exact estimation of the market size and its contribution to the parent market along with the precise estimation on upcoming trends and shifts in consumer behavior.

• This research provides growth analysis of the cluster headache market among regions such as North America, Europe, Asia Pacific and rest of the world.

• This report further provides comprehensive details of factors which will challenge the growth of cluster headache market players.

1. Executive Summary

2. Industry Outlook

3. Industry Overview

4. Industry Trends

5. Market Snapshot

6. Market Definition

7. Market Outlook

a. Porter Five Forces

8. Related Markets

9. Market characteristics

10. Market Overview

11. Market Segmentation

12. Market Dynamics

a. Drivers

b. Restraints

c. Opportunities

13. DRO - Impact Analysis

14. Drug class: Market Size & Analysis

15. Overview

16. Ergot derivatives

17. Calcium channel blockers

18. Triptans

19. Others

20. Distribution channel: Market Size & Analysis

21. Overview

22. Hospital pharmacies

23. Drug stores and retail pharmacies

24. Others

25. Type: Market Size & Analysis

26. Overview

27. Episodic

28. Chronic

29. Geography: Market Size & Analysis

30. Overview

31. North America

32. Europe

33. Asia Pacific

34. Rest of the World

35. Competitive Landscape

36. Competitor Comparison Analysis

37. Market Developments

a. Mergers and Acquisitions, Legal, Awards, Partnerships

b. Product Launches and execution

38. Vendor Profiles

39. Dr. Reddy’s Laboratories Ltd.

a. Overview

b. Financial Overview

c. Product Offerings

d. Developments

e. Business Strategy

40. Eli Lilly and Company

a. Overview

b. Financial Overview

c. Product Offerings

d. Developments

e. Business Strategy

41. Sun Pharmaceutical Industries Ltd.

a. Overview

b. Financial Overview

c. Product Offerings

d. Developments

e. Business Strategy

42. Teva Pharmaceutical Industries Ltd.

a. Overview

b. Financial Overview

c. Product Offerings

d. Developments

e. Business Strategy

43. FRESENIUS SE & Co. KGaA

a. Overview

b. Financial Overview

c. Product Offerings

d. Developments

e. Business Strategy

44. GlaxoSmithKline plc

a. Overview

b. Financial Overview

c. Product Offerings

d. Developments

e. Business Strategy

45. Pfizer Inc.

a. Overview

b. Financial Overview

c. Product Offerings

d. Developments

e. Business Strategy

46. Arrotex Australia Group

a. Overview

b. Financial Overview

c. Product Offerings

d. Developments

e. Business Strategy

47. Grunenthal

a. Overview

b. Financial Overview

c. Product Offerings

d. Developments

e. Business Strategy

48. Novartis AG

a. Overview

b. Financial Overview

c. Product Offerings

d. Developments

e. Business Strategy

49. Analyst Opinion

50. Annexure

51. Report Scope

52. Market Definitions

53. Research Methodology

a. Data Collation and In-house Estimation

b. Market Triangulation

c. Forecasting

54. Report Assumptions

55. Declarations

56. Stakeholders

57. Abbreviations

TABLE 1. GLOBAL CLUSTER HEADACHE MARKET VALUE, BY DRUG CLASS, 2021-2027 (USD BILLION)

TABLE 2. GLOBAL CLUSTER HEADACHE MARKET VALUE FOR ERGOT DERIVATIVES, BY GEOGRAPHY, 2021-2027 (USD BILLION)

TABLE 3. GLOBAL CLUSTER HEADACHE MARKET VALUE FOR TRIPTANS, BY GEOGRAPHY, 2021-2027 (USD BILLION)

TABLE 4. GLOBAL CLUSTER HEADACHE MARKET VALUE FOR OTHERS, BY GEOGRAPHY, 2021-2027 (USD BILLION)

TABLE 5. GLOBAL CLUSTER HEADACHE MARKET VALUE, BY DISTRIBUTION CHANNEL, BY GEOGRAPHY, 2021-2027 (USD BILLION)

TABLE 6. GLOBAL CLUSTER HEADACHE MARKET VALUE FOR HOSPITAL PHARMACIES, BY GEOGRAPHY, 2021-2027 (USD BILLION)

TABLE 7. GLOBAL CLUSTER HEADACHE MARKET VALUE FOR DRUG STORES AND RETAIL PHARMACIES, BY GEOGRAPHY, 2021-2027 (USD BILLION)

TABLE 8. GLOBAL CLUSTER HEADACHE MARKET VALUE FOR OTHERS, BY GEOGRAPHY, 2021-2027 (USD BILLION)

TABLE 9. GLOBAL CLUSTER HEADACHE MARKET VALUE, BY TYPE, 2021-2027 (USD BILLION)

TABLE 10. GLOBAL CLUSTER HEADACHE MARKET VALUE FOR EPISODIC, BY GEOGRAPHY, 2021-2027 (USD BILLION)

TABLE 11. GLOBAL CLUSTER HEADACHE MARKET VALUE FOR CHRONIC, BY GEOGRAPHY, 2021-2027 (USD BILLION)

TABLE 12. NORTH AMERICA CLUSTER HEADACHE MARKET VALUE, BY COUNTRY, 2021-2027 (USD BILLION)

TABLE 13. NORTH AMERICA CLUSTER HEADACHE MARKET VALUE, BY DRUG CLASS, 2021-2027 (USD BILLION)

TABLE 14. NORTH AMERICA CLUSTER HEADACHE MARKET VALUE, BY DISTRIBUTION CHANNEL, 2021-2027 (USD BILLION)

TABLE 15. NORTH AMERICA CLUSTER HEADACHE MARKET VALUE, BY TYPE, 2021-2027 (USD BILLION)

TABLE 16. U.S CLUSTER HEADACHE MARKET VALUE, BY DRUG CLASS, 2021-2027 (USD BILLION)

TABLE 17. U.S CLUSTER HEADACHE MARKET VALUE, BY DISTRIBUTION CHANNEL, 2021-2027 (USD BILLION)

TABLE 18. U.S CLUSTER HEADACHE MARKET VALUE, BY TYPE, 2021-2027 (USD BILLION)

TABLE 19. CANADA CLUSTER HEADACHE MARKET VALUE, BY DRUG CLASS, 2021-2027 (USD BILLION)

TABLE 20. CANADA CLUSTER HEADACHE MARKET VALUE, BY DISTRIBUTION CHANNEL, 2021-2027 (USD BILLION)

TABLE 21. CANADA CLUSTER HEADACHE MARKET VALUE, BY TYPE, 2021-2027 (USD BILLION)

TABLE 22. EUROPE CLUSTER HEADACHE MARKET VALUE, BY COUNTRY, 2021-2027 (USD BILLION)

TABLE 23. EUROPE CLUSTER HEADACHE MARKET VALUE, BY DRUG CLASS, 2021-2027 (USD BILLION)

TABLE 24. EUROPE CLUSTER HEADACHE MARKET VALUE, BY DISTRIBUTION CHANNEL, 2021-2027 (USD BILLION)

TABLE 25. EUROPE CLUSTER HEADACHE MARKET VALUE, TYPE, 2021-2027 (USD BILLION)

TABLE 26. GERMANY CLUSTER HEADACHE MARKET VALUE, BY DRUG CLASS, 2021-2027 (USD BILLION)

TABLE 27. GERMANY CLUSTER HEADACHE MARKET VALUE, BY DISTRIBUTION CHANNEL, 2021-2027 (USD BILLION)

TABLE 28. GERMANY CLUSTER HEADACHE MARKET VALUE, BY TYPE, 2021-2027 (USD BILLION)

TABLE 29. U.K CLUSTER HEADACHE MARKET VALUE, BY DRUG CLASS, 2021-2027 (USD BILLION)

TABLE 30. U.K CLUSTER HEADACHE MARKET VALUE, BY DISTRIBUTION CHANNEL, 2021-2027 (USD BILLION)

TABLE 31. U.K CLUSTER HEADACHE MARKET VALUE, BY TYPE, 2021-2027 (USD BILLION)

TABLE 32. FRANCE CLUSTER HEADACHE MARKET VALUE, BY DRUG CLASS, 2021-2027 (USD BILLION)

TABLE 33. FRANCE CLUSTER HEADACHE MARKET VALUE, BY DISTRIBUTION CHANNEL, 2021-2027 (USD BILLION)

TABLE 34. FRANCE CLUSTER HEADACHE MARKET VALUE, BY TYPE, 2021-2027 (USD BILLION)

TABLE 35. ITALY CLUSTER HEADACHE MARKET VALUE, BY DRUG CLASS, 2021-2027 (USD BILLION)

TABLE 36. ITALY CLUSTER HEADACHE MARKET VALUE, BY DISTRIBUTION CHANNEL, 2021-2027 (USD BILLION)

TABLE 37. ITALY CLUSTER HEADACHE MARKET VALUE, BY TYPE, 2021-2027 (USD BILLION)

TABLE 38. SPAIN CLUSTER HEADACHE MARKET VALUE, BY DRUG CLASS, 2021-2027 (USD BILLION)

TABLE 39. SPAIN CLUSTER HEADACHE MARKET VALUE, BY DISTRIBUTION CHANNEL, 2021-2027 (USD BILLION)

TABLE 40. SPAIN CLUSTER HEADACHE MARKET VALUE, BY TYPE, 2021-2027 (USD BILLION)

TABLE 41. ROE CLUSTER HEADACHE MARKET VALUE, BY DRUG CLASS, 2021-2027 (USD BILLION)

TABLE 42. ROE CLUSTER HEADACHE MARKET VALUE, BY DISTRIBUTION CHANNEL, 2021-2027 (USD BILLION)

TABLE 43. ROE CLUSTER HEADACHE MARKET VALUE, BY TYPE, 2021-2027 (USD BILLION)

TABLE 44. ASIA PACIFC CLUSTER HEADACHE MARKET VALUE, BY COUNTRY, 2021-2027 (USD BILLION)

TABLE 45. ASIA PACIFC CLUSTER HEADACHE MARKET VALUE, BY DRUG CLASS, 2021-2027 (USD BILLION)

TABLE 46. ASIA PACIFC CLUSTER HEADACHE MARKET VALUE, BY DISTRIBUTION CHANNEL, 2021-2027 (USD BILLION)

TABLE 47. ASIA PACIFC CLUSTER HEADACHE MARKET VALUE, BY TYPE, 2021-2027 (USD BILLION)

TABLE 48. CHINA CLUSTER HEADACHE MARKET VALUE, BY DRUG CLASS, 2021-2027 (USD BILLION)

TABLE 49. CHINA CLUSTER HEADACHE MARKET VALUE, BY DISTRIBUTION CHANNEL, 2021-2027 (USD BILLION)

TABLE 50. CHINA CLUSTER HEADACHE MARKET VALUE, BY TYPE, 2021-2027 (USD BILLION)

TABLE 51. INDIA CLUSTER HEADACHE MARKET VALUE, BY DRUG CLASS, 2021-2027 (USD BILLION)

TABLE 52. INDIA CLUSTER HEADACHE MARKET VALUE, BY DISTRIBUTION CHANNEL, 2021-2027 (USD BILLION)

TABLE 53. INDIA CLUSTER HEADACHE MARKET VALUE, BY TYPE, 2021-2027 (USD BILLION)

TABLE 54. JAPAN CLUSTER HEADACHE MARKET VALUE, BY DRUG CLASS, 2021-2027 (USD BILLION)

TABLE 55. JAPAN CLUSTER HEADACHE MARKET VALUE, BY DISTRIBUTION CHANNEL, 2021-2027 (USD BILLION)

TABLE 56. JAPAN CLUSTER HEADACHE MARKET VALUE, BY TYPE, 2021-2027 (USD BILLION)

TABLE 57. REST OF APAC CLUSTER HEADACHE MARKET VALUE, BY DRUG CLASS, 2021-2027 (USD BILLION)

TABLE 58. REST OF APAC CLUSTER HEADACHE MARKET VALUE, BY DISTRIBUTION CHANNEL, 2021-2027 (USD BILLION)

TABLE 59. REST OF APAC CLUSTER HEADACHE MARKET VALUE, BY TYPE, 2021-2027 (USD BILLION)

TABLE 60. REST OF WORLD CLUSTER HEADACHE MARKET VALUE, BY DRUG CLASS, 2021-2027 (USD BILLION)

TABLE 61. REST OF WORLD CLUSTER HEADACHE MARKET VALUE, BY DISTRIBUTION CHANNEL, 2021-2027 (USD BILLION)

TABLE 62. REST OF WORLD CLUSTER HEADACHE MARKET VALUE, BY TYPE, 2021-2027 (USD BILLION)

TABLE 63. DR. REDDY’S LABORATORIES LTD.: FINANCIALS

TABLE 64. DR. REDDY’S LABORATORIES LTD.: PRODUCTS & TYPES

TABLE 65. DR. REDDY’S LABORATORIES LTD.: RECENT DEVELOPMENTS

TABLE 66. ELI LILLY AND COMPANY: FINANCIALS

TABLE 67. ELI LILLY AND COMPANY: PRODUCTS & TYPES

TABLE 68. ELI LILLY AND COMPANY: RECENT DEVELOPMENTS

TABLE 69. SUN PHARMACEUTICAL INDUSTRIES LTD.: FINANCIALS

TABLE 70. SUN PHARMACEUTICAL INDUSTRIES LTD.: PRODUCTS & TYPES

TABLE 71. SUN PHARMACEUTICAL INDUSTRIES LTD.: RECENT DEVELOPMENTS

TABLE 72. TEVA PHARMACEUTICAL INDUSTRIES LTD.: FINANCIALS

TABLE 73. TEVA PHARMACEUTICAL INDUSTRIES LTD.: PRODUCTS & TYPES

TABLE 74. TEVA PHARMACEUTICAL INDUSTRIES LTD.: RECENT DEVELOPMENTS

TABLE 75. FRESENIUS SE & CO. KGAA: FINANCIALS

TABLE 76. FRESENIUS SE & CO. KGAA: PRODUCTS & TYPES

TABLE 77. FRESENIUS SE & CO. KGAA: RECENT DEVELOPMENTS

TABLE 78. GLAXOSMITHKLINE PLC: FINANCIALS

TABLE 79. GLAXOSMITHKLINE PLC: PRODUCTS & TYPES

TABLE 80. GLAXOSMITHKLINE PLC: RECENT DEVELOPMENTS

TABLE 81. PFIZER INC.: FINANCIALS

TABLE 82. PFIZER INC.: PRODUCTS & TYPES

TABLE 83. PFIZER INC.: RECENT DEVELOPMENTS

TABLE 84. ARROTEX AUSTRALIA GROUP: FINANCIALS

TABLE 85. ARROTEX AUSTRALIA GROUP: PRODUCTS & TYPES

TABLE 86. ARROTEX AUSTRALIA GROUP: RECENT DEVELOPMENTS

TABLE 87. GRUNENTHAL: FINANCIALS

TABLE 88. GRUNENTHAL: PRODUCTS & TYPES

TABLE 89. GRUNENTHAL: RECENT DEVELOPMENTS

TABLE 90. NOVARTIS AG: FINANCIALS

TABLE 91. NOVARTIS AG: PRODUCTS & TYPES

TABLE 92. NOVARTIS AG: RECENT DEVELOPMENTS

Methodology/Research Approach

This research study involved the extensive usage of both primary and secondary data sources. The research process involved the study of various factors affecting the industry, including the government policy, market environment, competitive landscape, historical data, present trends in the market, technological innovation, upcoming technologies and the technical progress in related industry, and market risks, opportunities, market barriers and challenges. The following illustrative figure shows the market research methodology applied in this report.

Research Programs/Design

Historical Data (2015-2019)	Industry Trends Competitive Landscape By Company Expansion Mergers and Acquisitions Market Segment by Type by Application By Regions/ Geography	Value Status and Outlook Value for Major Players Market Share Growth Rate Present Situation Analysis Value Market Share Growth Rate Present Situation Analysis
Influencing Factors	Market Environment Government Policy Technological Changes Market Risks	Market Drivers Growing Demand of Downstream Reduction in Cost
Market Forecast (2021-2026)	Overall Size by Type by Application By Regions/Geography	Key Data (Value) Market Share Growth Rate CAGR (2021-2026)

Market Size Estimation

Top-down and bottom-up approaches are used to validate the global Voluntary Carbon Offset market size market and estimate the market size for Company, regions segments, product segments and Application (end users).

The market estimations in this report are based on the marketed sale price of Voluntary Carbon Offset (excluding any discounts provided by the player, distributor, wholesaler or traders). The percentage splits, market share, and breakdowns of the product segments are derived on the basis of weights assigned to each of the segments on the basis of their utilization rate and average sale price. The regional splits of the overall Voluntary Carbon Offset market and its sub-segments are based on the percentage adoption or utilization of the given product in the respective region or country.

Major Company in the market is identified through secondary research and their market revenues determined through primary and secondary research. Secondary research included the research of the annual and financial reports of the top Company; whereas, primary research included extensive interviews of key opinion leaders and industry experts such as experienced front-line staff, directors, CEOs and marketing executives. The percentage splits, market share, Growth Rate and breakdowns of the product markets are determined through using secondary sources and verified through the primary sources.

All possible factors that influence the markets included in this research study have been accounted for, viewed in extensive detail, verified through primary research, and analyzed to get the final quantitative and qualitative data. The market size for top-level markets and sub-segments is normalized, and the effect of inflation, economic downturns, and regulatory & policy changes or other factors are not accounted for in the market forecast. This data is combined and added with detailed inputs and analysis from Market Intellix and presented in this report

The following figure shows an illustrative representation of the overall market size estimation process used for this study.

Market Breakdown and Data Triangulation

After complete market engineering with calculations for market statistics; market size estimations; market forecasting; market breakdown; and data triangulation, extensive primary research was conducted to gather information and verify and validate the critical numbers arrived at. In the complete market engineering process, both top-down and bottom-up approaches were extensively used, along with several data triangulation methods, to perform market estimation and market forecasting for the overall market segments and sub-segments listed in this report. Extensive qualitative and further quantitative analysis is also done from all the numbers arrived at in the complete market engineering process to list key information throughout the report.

Data Source

Secondary Sources

Secondary sources include such as press releases, annual reports, non-profit organizations, industry associations, governmental agencies and customs data, etc. This research study involves the usage of widespread secondary sources, directories, databases such as Bloomberg Business, Wind Info, Hoovers, Factiva (Dow Jones & Company), and TRADING ECONOMICS, and News Network, statista, Federal Reserve Economic Data, annual reports, BIS Statistics, ICIS; company house documents; CAS(American Chemical Society); investor presentations; and SEC filings of companies. Secondary research was used to identify and collect information useful for the extensive, technical, market-oriented, and Hospitals study of the Voluntary Carbon Offset market. It was also used to obtain important information about the top companies, market classification and segmentation according to industry trends to the bottom-most level, and key developments related to market and technology perspectives.

Market Size	Segmental value Geographic Penetration Product Adoption Rate for Different market	Journals, Websites, and Press Releases Annual Reports and SEC Filings Company Websites and Press Releases Public and Paid Databases Market Intellix Data Repository
Market Position of Top Company	Product Financials Geographic value Mix Total Company value Business/Segmental value Mix
Qualitative Analysis	Influence Factors Market Potential Market Risks and Opportunities Industry Trends Geographical Features Government Policies	Company Websites and Press Releases Public and Paid Databases Annual Reports Industry Associations Market Intellix Data Repository

Primary Sources

In the primary research process, various sources from both the supply and demand sides were interviewed to obtain qualitative and quantitative information for this report. The primary sources from the supply side include product Company (and their competitors), opinion leaders, industry experts, research institutions, distributors, dealer and traders, as well as the raw materials suppliers and producers, etc.

The primary sources from the demand side include industry experts such as business leaders, marketing and sales directors, technology and innovation directors, supply chain executive, end use (product buyers), and related key executives from various key companies and organizations operating in the global market.

Primary research was conducted to identify segmentation Type, product price range, product Application, key Company, raw materials supply and the downstream demand, industry status and outlook, and key market dynamics such as risks, influence factors, opportunities, market barriers, industry trends, and key player strategies.

Key Executives Interviewed

Key Data Information from Primary Sources

Primary Sources	Parameters	Key Data
Market Segments(by Application, by Type)	Value by Type Status and Forecast Value by Application Value by Regions, Status and Forecast (2021-2026)	Value Market Share by Type Value Growth Rate by Type Value by Application Percentage and Growth Rate by Application Value Growth Rate and Market Share by Regions Market Size Status and Forecast (2021-2026)
Total Market	Overall Size, Status and Forecast	Market Size Status and Forecast (2021-2026)